Neuromodulators and Dermal Fillers


Dermal filler injectable gel is for injection into areas of facial tissue where moderate to severe facial wrinkles and folds occur to temporarily add volume to the skin, especially around the nose and mouth, while there's also an injectable gel for deep injection in the cheek area to correct age-related volume loss in adults over the age of 21.

Neuromodulators are the only approved treatment to temporarily improve the appearance of both moderate to severe frown lines between the brows and crow’s feet lines (wrinkles at the outer corner of the eyes) in adults, among other wrinkles on the face.

Neuromodulators target one of the underlying causes of frown lines and crow’s feet—the repeated muscle contractions from frowning and squinting over the years. Injection of neuromodulators will temporarily reduce muscle activity. You will begin to notice a visible smoothing of your crow’s feet lines and frown lines between your brows.

After the short procedure, you may begin to notice results within 24 to 48 hours for moderate to severe frown lines, with results lasting up to 4 months.

These are cosmetic treatments administered through injections, more often in a physician’s office. Both the neurotoxin and dermal fillers are minimally invasive and are quite popular among patients seeking cosmetic treatment (Kaplan, 2014). The American Society of Plastic Surgeons reports that in 2015, the two accounted for over 9 million cosmetic procedures in the US. The neurotoxin is made up of purified bacteria, which when injected, freezes the muscles. By doing this, the neurotoxin helps lower the appearance of wrinkles and lines brought about by facial expressions. In huge amounts, the neurotoxin is dangerous and thus has to be utilized in small regulated quantities. On the other hand, Dermal Fillers contain ingredients that stimulate fullness in areas that have thinned out as a result of aging including the cheeks and lips.  


Gilbert, E., Hui, A., & Waldorf, H. A. (2012). The basic science of dermal fillers: past and present Part I: background and mechanisms of action. Journal of drugs in dermatology: JDD11(9), 1059-1068.
Hill, P. (2010). Botox, Dysport, Dermal Fillers, and Sclerotherapy. Delmar Cengage Learning
Kaplan, E. (2014). Cosmetic Injection Techniques: A Text and Video Guide to Neurotoxins and Fillers. Plastic and reconstructive surgery133(2), 462.
Kim, H. J., Seo, K. K., Lee, H. K., & Kim, J. (2016). Clinical Anatomy of the Face for Filler and Botulinum Toxin Injection. Springer Singapore.
Kontis, T. C., & Rivkin, A. (2009). The history of injectable facial fillers. Facial Plastic Surgery25(02), 067-072.